Researchers reverse Alzheimer's memory loss in mice

Credit Wikimedia Commons

Scientist have found that toxic bacteria in gum disease can travel to the brain, which could raise the risk of developing Alzheimer's in later life. Lab tests using mice demonstrated the potential of the bacteria Porphyromonas gingivalis to travel from the mouth of a subject to its brain, resulting in the destruction of neurons.

Researchers at Cortexyme, a San Francisco pharmaceutical company, are looking into a potential drug to block the gum bacteria's apparent effects in the brain.

'Success of this new drug depends on whether the infection really does play an important role in Alzheimer's disease.

Researchers say they've found more evidence linking bacteria found in a common type of gum disease to dementia.

It's possible that news of the possible link will lead to people spending more time on their dental health than they now do, though: One study found less than one third of Americans floss daily. In cell cultures, different forms of the gingipain enzyme damaged tau, another protein associated with Alzheimer's, and that damage may cause tau to develop into tangles, which are another indicator or Alzheimer's neurodegeneration, the researchers found in additional experiments.

The team also tested drugs in mice aimed at clearing the harmful bacteria and blocking its toxic enzymes. The team correlated the gingipain levels with pathology related to two markers: tau, a protein needed for normal neuronal function, and ubiquitin, a small protein tag that marks damaged proteins for degradation and is found in tau tangles and Aβ plaques. In both mice and human brain tissue, scientists discovered a drop in receptors for glutamate, a neurotransmitter in the brain necessary for both learning and short-term memory retention.

The study, published Thursday in the journal Science, suggests that a lack of adequate sleep can advance Alzheimer's while good sleep could help maintain brain health.

More news: Winter Weather Advisory In Effect
More news: Seamless Nadal drubs Australian Duckworth in Melbourne opener
More news: Man City boss Guardiola dismisses 'ridiculous' four-peat hopes

One drug, given to mice in food, effectively treated P. gingivalis brain infections and prevented the loss of memory neurons.

"Not enough people are asking what is upstream of the plaques ... and [brain] inflammation", said Lynch, who has a background in Alzheimer's research and was frustrated by the string of failed therapies for the disease. He hopes the test will allow researchers to monitor the effectiveness of new treatments before people have started to experience symptoms, by measuring how levels of the protein are affected.

It said Alzheimer's cases often had accumulation of proteins called amyloid and tau in the brain, and the main hypothesis so far had been that defective control of these proteins caused the disease.

Testing how NfL levels change could also become a useful way to develop new Alzheimer's treatments.

They found P. gingivalis DNA in 7 out of 10 cerebrospinal fluid samples of people with Alzheimer's disease and all 10 matched saliva samples.

These microorganisms that are the causative agents of chronic periodontitis, has been detected previously in the brain of deceased patients with Alzheimer's disease. The drug is now being tested in clinical studies. "It really will be important to see how this plays out in human randomized controlled trials, which is the gold standard for understanding whether a therapeutic targeting something like the P. gingivalis mechanism would actually be effective", she said.

Related News:

  • Presidential Candidate Kamala Harris To Put Headquarters In Baltimore

    Presidential Candidate Kamala Harris To Put Headquarters In Baltimore

    Harris made it official Monday with a social media video that also introduced her campaign slogan: "For the people". Still, he says Harris is on solid footing for the primaries, even with a large field of candidates expected.
    Japan, S.Korea remain split over radar incident

    Japan, S.Korea remain split over radar incident

    Speculation is mounting that a second meeting between Mr Kim and Mr Trump could be held in Vietnam. Kim Yong Chol earlier held talks with Secretary of State Mike Pompeo at a Washington hotel.
    R. Kelly accuser says he threatened to reveal her sex life

    R. Kelly accuser says he threatened to reveal her sex life

    The Associated Press does not typically name people alleging sexual abuse unless they come forward publicly, as Rodgers has done. He noted that the number of times Kelly's songs have been streamed online has climbed in recent days.
  • Giuliani walks back statements of Trump's involvement in Moscow project

    Giuliani walks back statements of Trump's involvement in Moscow project

    The whole thing is problematic for them, though, and maybe Giuliani doesn't understand this, that it's all one big conspiracy.... Mueller's team. "Make it happen", the sources said Trump told Cohen", BuzzFeed News reported .
    Microsoft wants you to tell it how to make PC gaming better

    Microsoft wants you to tell it how to make PC gaming better

    In other words, it's unclear at this time what a Microsoft 365 bundle will have to offer consumers, and Nadella did not elaborate. Microsoft's end-of-support announcement is actually dated December 21, 2018, but it's just now getting publicized, it seems.
    Meghan Markle sports $35 H&M dress for royal visit

    Meghan Markle sports $35 H&M dress for royal visit

    The move's already been applauded online as showing the Duchess' desire to keep a common touch for her time in the Royal family. Their Therapaws programme promotes the positive therapeutic impact that animals can have through visits to residential homes.
  • 10-Year-Old Wins Science Fair by Proving Tom Brady Cheated

    10-Year-Old Wins Science Fair by Proving Tom Brady Cheated

    Green Airport in Rhode Island for the flight to Atlanta where they will face the Los Angeles Rams in Super Bowl 53 on February 3. Brady has steadfastly denied the allegation and ended up helping the Patriots win Super Bowl LI after serving his suspension.
    Godfather II Scene Plays Cameo Role in Roger Stone Indictment

    Godfather II Scene Plays Cameo Role in Roger Stone Indictment

    You backstab your friends-run your mouth my lawyers are dying Rip you to shreds", Stone told the person in an April 9 email. When Trump considered running ahead of the 2012 and 2016 elections, Stone was one of the first consultants he turned to.
    Syrian air defences shoot down 'hostile targets': state media

    Syrian air defences shoot down 'hostile targets': state media

    Observatory chief Rami Abdel Rahman said that Sunday's blast appeared to be the first attack in Damascus in over a year. Israel has pledged to stop its main enemy Iran from entrenching itself militarily in neighboring Syria.
  • Giuliani says Cohen talked about Trump Tower in Moscow through 2016 election

    Giuliani says Cohen talked about Trump Tower in Moscow through 2016 election

    BuzzFeed's spokesman, Matt Mittenthal, issued a similar statement Saturday, even before Giuliani called for a leak probe. Trump said in November that he saw nothing wrong with running for president and pursuing a business deal simultaneously.
    Former NFL Head Coach Gary Kubiak Reportedly Lands New Job

    Former NFL Head Coach Gary Kubiak Reportedly Lands New Job

    With offensive line coach Mike Munchak in the fold, the Broncos will likely blend wide zone running schemes with power concepts. He helped Jimmy Garoppolo adjust after a midseason trade from New England that season, and Garoppolo won his first five starts.
    Giant spinning ice saucer forms in river

    Giant spinning ice saucer forms in river

    Ice discs like the one in ME are not uncommon when atmospheric conditions are just right, the Bangor Daily News reports . Photos of the circle went viral after being posted by Tina Radel, the city's marketing and communications director.


Most liked

3 more kids die of influenza: US CDC report
Cover your nose and mouth with a tissue when you cough or sneeze and throw the tissue in the trash, then wash your hands. About half of those people have sought medical care for the illness, including more than 100,000 who were hospitalized.

Family booted from American Airlines flight following complaints about their body odour
The airline's decision prompted an argument between the family and ground crew staff that was captured by Adler on video. He thought we don't take showers for that.

Boy wins science fair proving Tom Brady's a cheater
Brady has steadfastly denied the allegation and ended up helping the Patriots win Super Bowl LI after serving his suspension. The boy also made a prediction for the Patriots against the Los Angeles Rams in Super Bowl LIII in Atlanta on February 3.

How to watch Manchester United v Arsenal with ESPN+ for free
UK residents can watch Arsenal's clash with Manchester United live on BBC 1, channel 101 for both Sky and Virgin Media users. Solskjaer has confirmed that he will be without three men, who all miss the trip to the capital due to injury.

Viewer Photos Of The Super Blood Wolf Moon
The full eclipse began at 4.40 am in the United Kingdom and appeared red at 5.12 am, according to the Royal Astronomical Society. The Virtual Telescope Project shared a live stream of the lunar eclipse at its brightest above the skyline of Rome.

Government Shutdown Continues as President Trump's Compromise Attempt Doesn't Budge Democrats
Republicans hold a 53-47 majority in the Senate, but major legislation in the chamber nearly always requires a 60-vote majority. Trump had not directly responded to her call to delay the State of the Union speech till after the shutdown ends.

New England Patriots vs. Kansas City Chiefs Live Stream
Kicker Stephen Gostkowski nailed the last-second, game-winning field goal to seal the victory. He has seen action in two games, taking 99 defensive snaps.

Hewitt: Tomic is a clown and he tried to blackmail me
In the end I drew a line in the sand and haven't spoke to him since. "I'm not planning to play at the next tie", he said. However at present there were " cultural standards " not being met that were preventing any imminent return.

Halep vanquishes Venus, sets sights on Serena
Williams came into the match with a 3-2 record against the Romanian, but the last of those wins was back in 2013. It's the second time this week that someone Williams has beaten has cried after being beaten.

Here’s why Unai Emery wants Mesut Ozil to leave Arsenal this month
Unai Emery is now desperately trying to offload Ozil to free up funds to sign the midfielder. I am thinking about how he can help us.

China's moon lander sprouted a plant, but now it's dead
Inside you'll find soil, yeast, fruit fly and silkworm eggs, as well as cotton, potato, tomato, and (flowering) thale cress seeds. And even the cotton plant is looking pretty peaky compared to seedlings in a control setup the scientists established on Earth.

Kim Kardashian Confirms Big News About Her Family
Kourtney seemed shocked when Kim confirmed the baby's gender, saying "What?" You know, I've known him for 15 years now. I've known him forever, " she said ".

Trump Can't Bully AG Pick Into Interfering in Mueller Probe
Barr stopped short of directly pledging to release Mueller's report but expressed general support for disclosing the findings. Last year, Barr wrote a memo to Deputy Attorney General Rod Rosenstein critical of the Mueller probe.

Pompeo discusses USA drawdown in Syria with Turkish counterpart
Israeli officials have expressed worries that the pullout could give Iran greater leeway to entrench itself militarily in Syria. But, he added, "we also know that those are fighting alongside of us for all this time deserve to be protected as well".

Benjamin Netanyahu admits Israel to blame for Damascus strikes
Netanyahu added that Israel had attacked Iranian and Hezbollah targets in Syria hundreds of times, AFP news agency reported. According to the prime minister, Israel has attacked Iranian weapons depots at the Damascus International Airport in Syria.





Most Commented